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Document Type |
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Thesis |
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Document Title |
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PREPARATION AND CHARACTERIZATION OF SIMVASTATIN MUCOADHESIVE BUCCAL FILMS FOR ENHANCING THE DRUG BIOAVAILABILITY تحضير وتوصيف لصقات من السيمفاستاتين توضع بالفم لها القدرة على الإلتصاق بالأغشية المخاطية بهدف تحسين الإتاحة الحيوية للعقار |
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Subject |
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faculty of Pharmacy |
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Document Language |
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Arabic |
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Abstract |
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Simvastatin (SMV), a hypocholesterolemic agent, suffers from very low bioavailability due to its poor aqueous solubility and extensive first-pass metabolism. Two SMV carrier systems namely; polymeric drug inclusion complex (IC) and mixed micelles (MM), were developed and loaded into mucoadhesive buccal films to enhance SMV bioavailability. The two carrier systems were characterized and their permeation across human oral epithelial cells (OEC) was studied. The effect of IC to MM ratio (X1) and the mucoadhesive polymer concentration (X2) on the cumulative percent of drug released, elongation percent and mucoadhesive strength, from the prepared mucoadhesive films, was optimized. Ex-vivo permeation across bovine mucosal tissue was investigated. The permeation parameters, for the in-vitro and ex-vivo permeation data, were calculated. Complexation of SMV with hydroxypropyl beta-cyclodextrin (HP-β-CD) was superior to all other polymers as revealed by the equilibrium saturation solubility, stability constant, complexation efficiency and thermodynamic potential. SMV-HP-β-CD IC was developed utilizing the saturated polymeric drug solution. Both carrier systems showed enhanced permeation across OEC when compared to pure drug. X1 and X2 were significantly affecting the characteristics of the prepared films. The optimized mucoadhesive buccal film loaded with SMV-IC and drug -MM demonstrated superior ex-vivo permeation when compared to the corresponding pure drug buccal film, and the permeation parameters confirmed this finding. In summary, mucoadhesive buccal films containing SMV-IC and drug -MM can be used to improve drug permeation and so bioavailability, however, additional pharmacokinetic and pharmacodynamic studies are required. |
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Supervisor |
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Dr. Tarek Abdelnapy Ahmed |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1441 AH
2020 AD |
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Co-Supervisor |
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Dr. Bader Moubarak Aljeaid |
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Added Date |
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Thursday, June 11, 2020 |
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Researchers
| آلاء عمر باوزير | Bawazir, Alaa Omar | Researcher | Master | |
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