Document Details
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Document Type |
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Thesis |
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Document Title |
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ANTI-ADIPOGENIC AND ANTIOXDANT EFFECT OF ARTICHOKE (CYNARA SCOLYMUS) LEAVE EXTRACT IN OBESE RATS تأثير مستخلص اوراق الخرشوف المقاوم لتكون الدهون والمضاد للأكسدة في الجرذان المصابة بالسمنة |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Obesity is a worldwide health problem occurred due to various genetic and environmental factors. It caused different adverse effects such as impairment of some antioxidant enzyme activities and effects on liver tissues and other organs. The study aimed to investigate the role of supplementing low or high doses of water extract of artichoke leaves in rats fed high fat diet induced obesity. Fourteen rats were used in this study(10 rats/group), G1: control group, the other 30 rats fed on high fat diet for 8 weeks in order to induce obesity. After 8 weeks, rat groups were reordered as follow :G2 high fat diet group HFD (continued feeding on high fat diet ),G3 (Low dose + HFD) group rats supplemented 600 mg artichoke extract /kg b.w/day. and G4 (High dose + HFD) group rats supplemented 1500 mg artichoke extract /kg b.w/day, orally by gavages. After 3 weeks, rats were weighed and anesthetized by ether, blood samples were taken to use for determination of biochemical analysis then various organs (heart, liver, kidney and adipose tissue) were removed and relative weights organ were calculated. Results showed that (HFD) increased body weight, relative body organs weights, (BMI), atherogenic index, lipid parameters, liver function (AST, ALT), total, direct and indirect bilirubin, and caused negative effects on the antioxidant status (SOD, GSH, CAT, NO, TAC, MDA)the result also showed that HFD induced along with fat droplets accumulation between liver cells and increasing size of adipose tissues. Also disrupt the generic expression of LPL. These parameters were counteracted by supplementing either low or high dose of artichoke extract, indicating the mitigating effect of artichoke against (HFD) side effects. It was noticed that the hypolipidemic and antioxidant protective effects. |
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Supervisor |
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Prof. Rasha Hamed Mahmoud Hussein |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1440 AH
2018 AD |
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Co-Supervisor |
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Prof. Hanan Saeed Omar Alnahdi |
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Added Date |
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Monday, December 24, 2018 |
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Researchers
| مجد محمد عبد الخالق | Abdulkhaleq, Majd Mohammed | Researcher | Master | |
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