Document Details

Document Type : Thesis 
Document Title :
STUDY THE EFFECT OF ANETHUM GRAVEOLENS )DILL) SEEDS EXTRACT ON APOPTOSIS OF HUMAN COLON CANCER CELLS, HCT116
دراسة تأثير مستخلص بذور الشبت (anethum graveolens) على حث الموت المبرمج لخلايا سرطان القولون البشرية HCT116
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Colon cancer is one of the most serious health problems in developing and most developed countries. Furthermore, the incidence rate of this disease is steadily increasing over the past twenty years in Saudi Arabia. We aimed to examine the cytotoxic effects of Anethum graveolens (dill) extract on human colorectal cancer (CRC) cells (HCT116). Treatment of HCT116 cells with ethyl acetate dill seeds (EAD) significantly reduced cell viability. Calculated IC50, after 24, 48 and72 h, were 45, 35 and 25 μg/100 μl, respectively. EAD treated cells reduced colony formation and exhibited morphologic and biochemical features of apoptotic cell death. The induction of apoptosis was associated with increased ROS production, reduction in mitochondrial membrane potential and DNA damage and fragmentation. The molecular mechanism underlying the anti-cancer effect of EAD on HCT116 cells could be qualified as one of the promising targets for innovative treatment strategies of CRC. 
Supervisor : Dr. Abdul Qader Sheikh Omar 
Thesis Type : Master Thesis 
Publishing Year : 1440 AH
2019 AD 
Added Date : Monday, August 19, 2019 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
مها خليل طباشةTabasha, Maha KhalilResearcherMaster 

Files

File NameTypeDescription
 44871.pdf pdf 

Back To Researches Page