Main Page
Deanship
The Dean
Dean's Word
Curriculum Vitae
Contact the Dean
Vision and Mission
Organizational Structure
Vice- Deanship
Vice- Dean
KAU Graduate Studies
Research Services & Courses
Research Services Unit
Important Research for Society
Deanship's Services
FAQs
Research
Staff Directory
Files
Favorite Websites
Deanship Access Map
Graduate Studies Awards
Deanship's Staff
Staff Directory
Files
Researches
Contact us
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
PROPHYLACTIC EFFECT OF DATE PALM FRUIT EXTRACT AGAINST DOXORUBICIN-INDUCED HEPATOTOXICITY IN MALE WASTER ALBINO RATS
التأثير الوقائي لمستخلص ثمار التمر إزاء التسمم الكبدي المستحث بالدوكسوروبيسين في ذكور الجرذان البيضاء
Subject
:
faculty of science
Document Language
:
Arabic
Abstract
:
Background: This study evaluated the possible prophylactic efficacy of date palm fruit aqueous extract (DPFAE) in alleviation of the hepatotoxicity induced by doxorubicin (DOX) injection. Materials and methods: Wistar albino rats were equally and randomly divided to six groups: group 1: the untreated control, groups 2&3: rats were received daily oral prophylactic doses (0.75 & 1.5 of mg/kg bw of DPFAE) respectively for 30 days. Rats of groups 4, 5 & 6 were injected with a single intra-peritoneal dosage of DOX (15 mg/kg) on the 30th day of the study. However, rats of groups 5 & 6 received a daily oral protective doses of DPFAE (0.75 & 1.5 mg/kg bw respectively) for 30 days. Serum samples were used for estimation of ALT, AST, γ-GT and ALP by the optimized standard kinetic method. T. bilirubin, Total protein, Albumin were estimated by direct colorimetric method. Liver was divided into three fragments. One fragment was soaked immediately into 10% buffered neutral formaldehyde solution and managed for histopathologic examination, the second fragment was utilized for DNA extraction and the third fragment was utilized for preparation of liver tissue homogenate. Results: Treatment with DPFAE significantly ameliorated the altered liver enzymes and significantly improved rest of the liver profile as well as oxidative stress markers. This was together with major improvement in the hepatic histopathological features. Conclusion: The present results revealed that DPFAE seems to improve DNA damage of DOX-induced hepatotoxicity indicating the influence of DPFAE in restoring the functional ability of hepatic cells towards normalization. DPFAE was able to deactivate reactive oxygen species, suppressing lipid peroxidation and DNA injury.
Supervisor
:
Dr. Mohamed Kamel Abo-Golayel
Thesis Type
:
Master Thesis
Publishing Year
:
1441 AH
2020 AD
Co-Supervisor
:
Dr. Othman Abobaker Baothman
Added Date
:
Tuesday, February 11, 2020
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
أحمد محمد الفتني
Al Fattani, Ahmed Mohammed
Researcher
Master
Files
File Name
Type
Description
45868.pdf
pdf
Back To Researches Page