Document Details
|
Document Type |
: |
Thesis |
|
Document Title |
: |
Effect of Nigella sativa Oil on Female Rats Exposed to Lead تأثير زيت الحبة السوداء على اناث الجرذان المعرضة للرصاص |
|
Subject |
: |
Faculty of Science |
|
Document Language |
: |
Arabic |
|
Abstract |
: |
In recent decades, the environmental pollution is considered as one of the major health problems. The excessive levels of environmental pollution play a crucial role in the occurrence of many diseases. Heavy metals are harmful and toxic to man and environment even at low concentration because of their non-biodegradable nature, long biological half-life and their potential to accumulate in soil, plants and animals. Lead is a soft, malleable, heavy metal usually occurs in nature in small amounts. Medicinal plants play an important role in health care around the world. The present study is the first detailed experimental research designed to assess the protective effect of Nigella sativa oil (NSO) on female rats exposed to lead acetate. In this study, 40 female rats were equally allocated into 4 groups. Rats of the first group (G1) were served as normal controls. Rats of the second group (G2) were given 150mg/kg body weight lead acetate day after day. Rats the third group (G3) were orally administered with 700 mg/kg body weight NSO and after three hours gave the same dose of lead acetate given to group two. Rats of the fourth group were orally supplemented with the same dose of NSO given to group three. After six weeks of treatment, the clinical signs, biochemical and histological changes were investigated. Body weight loss, elevation of serum glucose, liver enzymes, total bilirubin, uric acid, urea, creatinine, triglycerides, cholesterol, low density lipoprotein-cholesterol and very low density lipoprotein-cholesterol and a decrease in the serum high density lipoprotein-cholesterol, catalase, malondialdehyde, reduced glutathione and superoxide dismutase levels were observed in lead-intoxicated rats. Daily oral administration of NSO to lead-intoxicated rats significantly amended the studied parameters. The histopathological examination of liver and kidney tissues in lead-intoxicated rats administered with NSO showed that the oil protect the liver and kidney against the damaging effect of lead acetate. The results of present study showed that the oil exhibited antihyperglycemic, antihyperlipidemic and antioxidant actions. Moreover, the findings of this investigation suggest that this oil could be used as effective and protective factors against the toxicity of lead due to its antioxidant properties. |
|
Supervisor |
: |
Dr. Isam ELDin Mohamed ELAmin Abu Zeid |
|
Thesis Type |
: |
Master Thesis |
|
Publishing Year |
: |
1441 AH
2020 AD |
|
Co-Supervisor |
: |
Dr. Naser Ahmad Hamad Al-Kenani |
|
Added Date |
: |
Sunday, May 17, 2020 |
|
Researchers
| ماجدة هادى المسعري | Al-Massari, Majdah Hadi | Researcher | Master | |
|
Back To Researches Page
|