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Document Type |
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Thesis |
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Document Title |
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POTENTIAL EFFECTS OF GARLIC OIL AND CURCUMIN ON CARBON TETRACHLORIDE-INDUCED LIVER INJURY IN RATS التأثيرات المحتملة لزيت الثوم و الكركم على كبد الجرذان المصابة برابع كلوريد الكربون |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Liver disease is the major cause of serious health problem leading to morbidity and mortality worldwide and the problem has increased in search for hepatotherapeutic agents from plants. The present study was designed to investigate the protective effect of garlic oil (GO) and curcumin (CUR) on carbon tetrachloride (CCl4) induced liver damage in male rats. Forty Wistar Albino rats weighting about (250-270 g) were divided into five groups (n=8). The 1st Group (G1) was the negative control group. The remaining goups were injected with CCl4 and equal amount of paraffin oil (1 ml/kg b.wt.) every 72 hours at 3 doses. The 2nd group (G2) was the positive CCl4 control group, the 3rd group (G3) and the 4th group (G4) were treated orally with GO (200 mg/kg b.wt.) and CUR (100 mg/kg b.wt.), respectively daily for 4 weeks. The 5th group (G5) was treated orally with a mixture of GO and CUR daily for 4 weeks. The results showed that the CCl4 positive control group exhibited very highly significant (p<0.001) elevation in levels of hepatic enzymes; aspartate and alanine aminotransferases, alkaline phosphatase and L-γ-glutamyl transferase. A decrease in reduced glutathione, glutathione peroxidase, glutathion-S-transferase, catalase, superoxide dismutase and high density lipoprotein cholesterol. An increase in total cholesterol, triglyceride, low density lipoprotein and malondialdehyde (MDA) when compared with negative control group. Histological changes of the CCl4 treated group revealed damage of liver tissues with inflammation. The administration of garlic oil, curcumin and their combination in G3, G4 and G5 , respectively showed significant improvment by restoring the altered biochemical and histopathological parameters. The combination of garlic oil and curcumin was more effective than either GO or CUR, separately. In conclusion, this study revealed that the use of GO, CUR and their combination have protective effect against CCl4-induced hepatotoxicity in male rats. |
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Supervisor |
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Prof. Chinese Noah's praise |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1443 AH
2022 AD |
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Added Date |
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Tuesday, March 15, 2022 |
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Researchers
| أميرة علي القحطاني | Al-Qahtani, Amira Ali | Researcher | Master | |
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