Document Details

Document Type : Thesis 
Document Title :
Molecular detection of Myocardial Infarction (MI) mutations related to cardiae sudden death
الكشف الجزيئي لبعض طفرات احتشاء عضلة القلب (نوبة قلبية) ذات الصلة بالموت القلبي المفاجئ
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : A common complication of coronary artery disease and the leading cause of death worldwide is myocardial infarction (MI). Myocardial infarction (MI) is one of the world's most prevalent cardiovascular diseases and has been considered the leading human cause of mortality. Sudden cardiac death is a catastrophic clinical occurrence that, in its normal and interfered phase, is temporally correlated with MI. It is linked to electrical myocardial instability, chronic ischemia and heart rupture in the early stages, whereas it is linked to myocardial remodeling leading to macro reentrant VT in the later phases. In this study evaluating genetic markers known to be associated with MI especially in Saudi Arabia. PCR multiplex primers for amplification of six PCR products to analyze six SNPs in five genes rs41411047(RNF13), rs32793(PDZD2), rs4739066(YHDF3), rs2487928(JCAD), and rs1333045 and rs10757274 (CDKN2-AS1). 100 MI patients’ samples and 100 control samples. two SNPs rs2487928 (JCAD) and rs10757274 (CDKN2-AS1) showed significant results after comparative research on chi-square and a distinction between the case group and the control group. 
Supervisor : Prof. Sherif Ahmed Edris 
Thesis Type : Master Thesis 
Publishing Year : 1443 AH
2022 AD 
Co-Supervisor : Prof. Jumana Yousuf Al-Aama 
Added Date : Monday, January 16, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
آلاء حسن الزهرانيAlzahrani, Alaa HassanResearcherMaster 

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