Document Details

Document Type : Thesis 
Document Title :
New Synthesis of Thiopurine and Thioumazine Derivatives and study of their Biological Activities.
تحضير بعض مشتقات الثيوويوراسيل المندمجة الجديدة ودراسة التأثير البيولوجي لها
 
Subject : New Synthesis of Thiopurine and Thioumazine Derivatives and study of their Biological Activities. 
Document Language : Arabic 
Abstract : Several 1-methyl-6-substitued -2-thiopyrimido[4,5-d]pyrimidines-4-one,ethyl-7-amino-5-aryl-1-methyl-4-oxo-2-thio-pyrido[2,3-d]pyrimi-dine- 6-carboxylate were synthesized by treatment of 6-amino-1-methyl-2-thiouracil with primary amines and formaldehyde 40%, and with ethyl 3-arylcyano olefins-3-carboxylate respectively. 7-Hydroxy-3-methyl-8-substituted-2-thioxanthines were synthesized by the treatment of 6-amino-1-methyl-5-nitroso-2-thiouracil with benzylidine anilines. Synthesis of 8-aryl-3-methyl-2-thioxanthines was achieved from 6-amino-1-methyl-2-thiouracil. On the other hand, the treatment of 5-nitroso-, or 5-amino-2-thiouracil derivatives with phenacyl bromides in presence of ZnCl2 afforded 7-aryl- and 6-aryl-2-thiolumazines respectively. The antiviral and antimicrobial studies were performed for the . All the new compounds were performed by elemental and spectral analyses and the antimicrobial analysis was carried out for some of them. 
Supervisor : Dr. 
Thesis Type : Doctorate Thesis 
Publishing Year : 1429 AH
2008 AD 
Added Date : Saturday, May 9, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
فاطمة عبدالعزيز عقيليAgili, Fatimah AbdulazizResearcherDoctorate 

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 19941.pdf pdf 

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