Document Details

Document Type : Thesis 
Document Title :
Lipoprotein (a) Level in Saudi Children with Steroid Resistant Nephrotic Syndrome
مستوى البروتين الدهني (أ) في الأطفال السعوديين المصابين بالمتلازمةالكلوية المقاومة للاستيرويد
 
Subject : Faculty of Sciences 
Document Language : Arabic 
Abstract : The nephrotic syndrome is frequently associated with hyperlipidemia leading to an increased coronary or thrombotic risk, which may be enhanced by high lipoprotein (a) [Lp(a)] concentration. The aim of the present study is to determine the level of Lp(a) in Saudi children with steroid resistant nephrotic syndrome. The medical records of 38 children with nephrotic syndrome were analyzed they were seen in King Abdulaziz University Hospital with age range of (4-16) years. These patients were divided into three groups. Group 1 consisted of 13 patients who were sensitive to steroid therapy (8.75±0.85).Group 2 consisted of 14 patients who were in remission (7.71±0.99) and group 3 consisted of 11 patients who were resistant to steroid therapy (10.1±1.13). A fourth control group was also included consisting of 27 healthy children. Serum lipoprotein (a), apolipoprotein AI and apolipoprotein B was measured using ELISA test. Serum cholesterol, triglyceride, HDL, LDL, albumin, creatinine and total proteins were also determined. This study demonstrated that Lp (a) levels were significantly higher in subjects who were resistant to steroid therapy (SRNS group) compared to control subjects and there was also significant decrease in albumin level in this group. Tha study showed also that all atherogenic lipids (cholesterol, triglyceride, LDL) were highly significant in children with SRNS. There were no significant correlation between Lp (a) and other lipoprotein lipids and apolipoprotein levels. The increased level of Lp (a) in steroid resistant nephrotic syndrome group indicates that they are at risk of cardiovascular disease. 
Supervisor : Prof. Dr. Amina Mohammad Medhat 
Thesis Type : Master Thesis 
Publishing Year : 1431 AH
2010 AD 
Co-Supervisor : Prof. Dr. Jameela Abdulaziz Kari .Dr. Sawsan Omar Khoja 
Added Date : Tuesday, December 7, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
منال عبد الباري طاشكنديTashkandi, Manal AbdulbariResearcherMaster 

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