Document Details

Document Type : Thesis 
Document Title :
The prevalence of thrombophilic genes mutations in women with recurrent spontaneous abortion in Saudi population
انتشار طفرات مورثات تخثرالدم لدى النساء المصابات بالاجهاض التلقائي المتكرر في السعودية
 
Subject : Biochemistry department 
Document Language : Arabic 
Abstract : Factor V G1691A, prothrombin G20210A and MTHFR C677T are major inherited thrombophilia. Recently, a possible relationship between inherited thrombophilia and recurrent spontaneous abortion has been suggested. Most inherited thrombophilic cases remains asymptomic and the presence of a hypercoagulable state, like pregnancy, acts as a trigger to initiate clot formation in placenta which results in pregnancy complications, still birth and abortion. The aim of this study was to determine the frequency and prevalence of the thrombophilic mutations (FVL, prothrombin and MTHFR) in Saudi women diagnosed with unexplained recurrent spontaneous abortion (RSA). Forty six women diagnosed with unexplained recurrent abortion (age between 20-35 years) was compared with forty two women with uncomplicated pregnancy. The DNA was extracted from peripheral blood for all samples. Genotype analysis for the three mutations: factor V G1691A, prothrombin G20210A and MTHFR C677T were determined by PCR and RFLP using Mnl I, HindIII and HinfI restriction enzymes digestion, respectively. Mutation frequencies were (2.2% vs. 0%) for Factor V G1691A, (0% versus 2.2%) for prothrombin G20210A and (21.3% vs. 31%) for MTHFR in RSA patients against controls. The prevalence of the mutations were not significantly different between RSA patient and controls. In conclusion, our results show that inherited thrombophilia was not found to be associated with recurrent pregnancy loss on Saudi population. 
Supervisor : Prof. Dr. Taha Abdullah Kumosani 
Thesis Type : Master Thesis 
Publishing Year : 1432 AH
2011 AD 
Co-Supervisor : Dr. Mohammed Hussain Alqahtani 
Added Date : Tuesday, September 27, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
نوف عوده الشريفAlshareef, Nouf OwdahResearcherMaster 

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