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Document Type |
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Thesis |
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Document Title |
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Collagen Type 1 alpha 1 gene polymorphism and its relationship to osteoporosis in postmenopausal Saudi women الأشكال المتعددة لجين الكولاجين النوع الأول ألفا1 وعلاقته بهشاشة العظام لدى السيدات السعوديات ما بعد سن انقطاع الطمث |
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Subject |
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Biochemistry department |
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Document Language |
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Arabic |
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Abstract |
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Osteoporosis is a common disease with a strong genetic component characterized by low bone mass, micro-architectural deterioration of bone tissue and an increased risk of fracture. In this study, the association between a common polymorphism of collagen type 1 α1 gene (Sp1) and osteoporosis risk in postmenopausal Saudi women was evaluated. To the best of our knowledge, this is the first report on genotype distribution and allele frequency of the COL1A1 in postmenopausal Saudi women. This study included 80 postmenopausal Saudi women, living in Jeddah, Saudi Arabia, with an age range of 45-85 years., that were divided into groups according to bone mineral density (BMD) (T-score) at two sites (lumbar spine and femoral neck) as determined by DXA. Measuring BMD at lumbar spine, subjects were classified as 30 with osteoporosis, 21 with osteopenia and 29 were normal. Measuring BMD at the femoral neck, 11 had osteoporosis, 34 had osteopenia and 35 had normal BMD. Genotypes were determined for all subjects by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Contingency analysis was performed for risk estimation. It was that in the osteoporosis and osteopenia groups at the lumbar spine site carriers of the variant T-allele of Sp1 polymorphism had a higher risk than carriers of the normal (GG) genotype (OR= 1.5; P= 0.27 and OR= 1.1; P= 0.92, respectively), and while at the femoral neck site in the osteoporosis and osteopenia groups, that carriers of the variant T-allele of Sp1 polymorphism had a higher risk than carriers of the normal (GG) genotype (OR= 1.1; P= 1 and OR= 1.2; P= 0.61, respectively). These results suggest that the T-allele of Sp1 polymorphisms might be a risk factor for osteoporosis. These findings suggest that genetic polymorphisms (Sp1) in COL1A1 gene may play an important role in the development of osteoporosis in postmenopausal Saudi women. |
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Supervisor |
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Dr. Archana Panchapakesan Iyer |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1433 AH
2012 AD |
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Co-Supervisor |
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Prof. Mohamad Hasan Qari |
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Added Date |
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Monday, January 30, 2012 |
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Researchers
| ناهد صائل الحارثي | Al-Harthi, Nahed Sail | Researcher | Master | |
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