Document Details
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Document Type |
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Thesis |
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Document Title |
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Biochemical markers of Bone Turnover in Obese Postmenopausal Saudi Women with Type-ІІ Diabetes Mellitus دلالات تحول العظم الكيميائية الحيوية في النساء السعوديات البدينات بعد سن اليأس المصابات بداء السكري من النوع الثاني |
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Subject |
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Biochemistry department |
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Document Language |
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Arabic |
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Abstract |
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Diabetes mellitus is defined as a group of metabolic disorders characterized by hyperglycemia. Type 2 diabetes (T2DM), which is the most prevalent form of diabetes mellitus with 90-95% of total cases, is characterized by insulin resistance and relative insulin deficiency. It is a major public health problem worldwide, obesity has long been recognized as one of the strongest risk factors for development of this disease. It has been estimated to account for 60% to 90% of the risk variance. Patients with type 2 diabetes mellitus display an increased fracture risk and bone problems. In this study we evaluate the relationship between T2DM and bone turnover as a problem in diabetic obese postmenopausal Saudi women. This has been investigated through studying the biochemical parameters in the serum ]fasting blood glucose (FBG), calcium (Ca), phosphorus (Pi), parathyroid hormone (PTH), 1,25-(OH)2Vit.D3 ,osteocalcin (OC), procollagen (PICP) and cathepsin k (Cath K) [. The present study included 65 T2DM obese postmenopausal Saudi group (36 uncontrolled, 29 controlled) attending Medical Administration at King Abdul Aziz University and 20 healthy postmenopausal Saudi subjects as control group. The diabetic obese postmenopausal Saudi group were classified according to glycated hemoglobin ( HbA1c) into two subgroups controlled and uncontrolled. Bone turnover markers were measured by Enzyme-linked immunosorbent assay (ELISA) technique. Data are presented as means ± SD. Differences between the experimental groups were determined by performing a one way analysis of variance (ANOVA, version 15). Results of this study showed that serum OC levels were significantly decreased in diabetic obese postmenopausal Saudi group compared to their respective healthy group (P < 0.004). PICP and Cath K were significantly higher increase in diabetic postmenopausal Saudi group compared to their healthy group ( P < 0.024 & 0.0001). Our results showed a significant increase in 1,25(OH)2 Vit.D3, Ca and Pi levels in diabetic obese postmenopausal Saudi patients group compared to their healthy group. On other hand, serum PTH concentrations were non-significant difference between the studied groups (P < 0.659). Also, our results showed a significant increase in BMI, FBG, HbA1c, systolic and diastolic blood pressure in patients group compared to their healthy group ( P < 0.001, 0.0001, 0.0001, 0.032 and 0.022). In this study, the changes in the biochemical parameters and obesity are strong risk factor for diabetes development that contribute to the bone problems. So, this study contributed to the showed impact of T2DM on biochemical markers of bone turnover in obese postmenopausal Saudi women. |
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Supervisor |
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Prof. Dr. Jalaluddin A. Jalal Khan |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1433 AH
2012 AD |
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Co-Supervisor |
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Prof. Dr. Amani Farouk H. Noureldeen |
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Added Date |
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Tuesday, July 10, 2012 |
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Researchers
| ندا محمد السلمي | ALSelami, Nada Mohammed | Researcher | Master | |
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