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Document Type |
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Thesis |
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Document Title |
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Bone Status in Breast Cancer Treated Women حالة العظم في النساء المصابات بسرطان الثدي وتحت العلاج |
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Subject |
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Biochemistry department |
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Document Language |
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Arabic |
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Abstract |
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The incidence of breast cancer has steadily increased in the industrialized world during the recent 50 years with an estimated incidence of 13.8% among Saudi women in 2007. Patients treated for breast cancer are at increased risk for osteoporosis and increased incidence for bone fractures which may adversely affect their quality of life, even if they achieve a complete cure of their malignancy. The goal of the present study was to detect bone status in postmenopausal women under treatment for breast cancer, so that osteoporosis and hence bone fracture could be avoided in Saudi female patients. In this study we evaluated the relationship between breast cancer treatments and bone turnover as a problem in postmenopausal women. Levels of serum calcium, phosphate, parathyroid hormone, 25-hydroxy vitamin D, tumor necrosis factor-α, interlukin-1, interlukin-6, osteocalcin, C-terminal propeptid of type-1 collagen and cathepsin k were determined. The present study included 67 postmenopausal breast cancer treated patients and 15 newly diagnosed postmenopausal breast cancer patients.The treated postmenopausal patient groups were classified according to the type of treatment they were taken (57 chemotherapy and 10 tamoxifen treated). Chemotherapy treated groups was further subdivided in to four subgroups according to chemotherapy doses. Results indicated significantly higher mean serum calcium and phosphate in tamoxifen treatment relative to untreated and chemotherapy treated patients. Inflammatory cytokines were none significantly changed between groups and all individual values were within normal range. On other hand, serum parathyroid hormone concentrations showed non-significant difference between the studied groups. Results also indicated significantly elevated serum vitamin D in breast cancer patients treated with tamoxifem compared to untreated patients and chemotherapy treated subgroups. No significant difference between treated and untreated breast cancer for osteocalcin, carboxy-terninal propeptide of type I collagen. None detectable cathepcin K values were observed in almost all patients groups, indicating minor changes in bone resorption which were not detected. It could be concluded that tamoxifen and chemotherapy treatment at tested doses had no significant effect on bone turnover rate. On the other hand, tamoxifen did improve vitamin D status compared to other groups in breast cancer patients. |
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Supervisor |
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Prof. Dr. Amani Farouk H. Noureldeen |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1434 AH
2013 AD |
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Co-Supervisor |
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Dr. Hana Mohamed Gashlan |
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Added Date |
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Wednesday, January 16, 2013 |
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Researchers
| وفاء طلعت عرب | Arab, Wafaa Talaa | Researcher | Master | |
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