Document Details

Document Type : Thesis 
Document Title :
Early Maternal Adipocytokines Levels for Prediction of Subsequent Development of Gestational Diabetes Mellitus
المستويات المبكرة للأديبوسيتوكينات في الإناث الحوامل للتنبؤ بحدوث الحمل السكري لاحقا
 
Subject : Biochemistry department 
Document Language : Arabic 
Abstract : Gestational diabetes mellitus (GDM) is a common medical complication associated with pregnancy. Approximately 40% of women with GDM during their pregnancy will go on to develop type 2 diabetes mellitus. The incidence of GDM in Saudi Arabia ranges from 3.8% to 12.5%. GDM increases the incidence of complications in both mother and fetus. Newborns of mothers with GDM are at increased risk for acute perinatal complications. Adipocytokines secreted by adipose tissue were found to be involved in the process of insulin resistance associated with GDM. The goal of the present study was to evaluate the extent to which maternal adipocytokines (leptin, adiponectin, resistin, visfatin and tumor necrosis factor-alpha [TNF-α]) are associated with the risk of developing GDM. The study included total number of 142 pregnant women classified into 4 groups: normal pregnancy (n=33) and pregnancy with GDM (n=24) both at 2nd trimester and normal pregnancy (n=38) and GDM (n=47) at 3rd trimester. Both GDM and control groups were matched for gestational age, although GDM groups were significantly presented with elevated body mass index (BMI), fasting blood sugar and abnormal oral glucose tolerance test compared to their matched control. Results indicated reduction in maternal serum leptin and adiponectin in GDM compared to normal pregnancy at both tested trimesters; being only significant at 3rd. Elevated resistin and TNF-α were evident among pregnancy complicated with GDM. On the other hand, significant elevation in maternal visfatin was noted between GDM and matched control at 2nd trimester only. Significant increases in maternal leptin and visfatin with reduction in resistin were noted by advanced gestational period in healthy pregnancy. On the other hand reduced adiponectin and elevated visfatin mean values were noticed in GDM at 3rd compared to 2nd trimester. Results also indicated no significant change in all studied adipocytokines in control or GDM by increasing BMI either at 2nd or 3rd trimesters. It could be concluded that increased insulin resistance accompanies GDM is associated with suppressed leptin and adiponectin and increased resistin and TNF-α which suggest strongly their involvement in the development of GDM. 
Supervisor : Prof. Amani Farouk Hussein Noureldeen 
Thesis Type : Master Thesis 
Publishing Year : 1434 AH
2013 AD 
Co-Supervisor : Prof. Hassan Salah Abduljabbar 
Added Date : Saturday, April 13, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
مرام حسين باقيسBagais, Maram HusseinResearcherMaster 

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