Document Details

Document Type : Thesis 
Document Title :
Matrix Metalloproteinases in Colorectal Cancer
أنزيمات البروتينيز المعدنية للنسيج البين خلوي في سرطان القولون والمستقيم
 
Subject : Biochemistry department 
Document Language : Arabic 
Abstract : The current staging system along the conventional prognostic factors is the gold standard for prognosis for colorectal cancer (CRC). In spite of that, it is unable to distinguish those patients who might carry high risk of recurrence and poor outcome. Hence, the seek for new molecular factors that could stratify patients into different risk categories is highly in need. This study is aimed to assess the expression of selected group of matrix metalloproteinases (MMPs); MMP-2, MM-7 and MMP-9 in a subset of primary CRC and determine its relation to different clinico-pathological factors and survival. To achieve this, paraffin blocks of 127 CRC patients were retrieved. Antigen expressions of MMP-2, -7 and -9 were analyzed by immunohistochemistry (IHC) and their cytoplasmic and stromal staining was evaluated. Statistical analyses were performed to determine the association of these MMPs with clinico-pathological variables. The results showed that overexpressions of both MMP-2 and MMP-9 were a significant sign of poor outcome and recurrence as evaluated by univariate Kaplan–Meier for disease-free survival (DFS) (p= 0.012, p= 0.001) and disease-specific survival (DSS) (p= 0.012, p= 0.038). In multivariate survival (Cox) analysis, MMP-2 and -9 also were significant independent predictors of DFS (p= 0.006, p=0.018) and DSS as well (p= 0.004, p=0.049). On the other hand, MMP-7 exhibits no prognostic power in for recurrence and poor survival. These results implicate the usefulness of MMP-2 and -9 expressions in predicting outcome of patients with CRC. 
Supervisor : Prof. Ibrahim Hasan Kamal 
Thesis Type : Master Thesis 
Publishing Year : 1434 AH
2013 AD 
Co-Supervisor : DR.Adel Mohammed Abuznadeh 
Added Date : Thursday, September 12, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ندى فيصل سالمSalem, Nada FaisalResearcherMaster 

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