Document Details
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Document Type |
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Thesis |
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Document Title |
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Regulation of CD36 Gene Expression by Hibiscus sabdariffa tea to prevent atherosclerosis in Saudi Women تنظيم التعبير الجيني للجين CD36 عن طريق شاي الكركدية لمنع تصلب الشرايين في النساء السعوديات |
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Subject |
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Faculty of Home Economics |
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Document Language |
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Arabic |
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Abstract |
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Cardiovascular diseases share a major segment of the total mortality rate 46% in Saudi Arabia. There are indications of an association between the bioactive components in Hibiscus sabdariffa, in preventing atherosclerosis, the major cause of (CVD). An intervention study therefore was planned to investigate this relationship more deeply with modern molecular parameters. Thus, the main focus aimed to see the effect of anthocyanins from H. sabdariffa tea on the atherosclerosis biomarkers and role of this extract on regulating CD36 gene expression in human. The blood sample were collected and Blood pressure (BP) was measured twice for 16 participants. In addition, subjects were asked to complete a dietary record of three days before the intervention. Anthropometric measurements were determined at baseline, and a usual diet was followed while consuming the H. sabdariffa tea twice a day for six consecutive weeks. Following termination of exposure period blood samples were withdrawn. Measurement showed that systolic and diastolic pressure was lowered (P=0.000, P=0.005, P < 0.05). The antioxidant concentration showed however, no significant differences (P = 0.346, P > 0.05). The results revealed that the OxLDL levels were decreased significantly (P=0.013, P< 0.05). Even though there was no significant difference for the LDL, TG, TC, GLU levels, in contrast, HDL did increase. Another result of special interest was that the CD36 gene expression significantly experienced a down regulation at the gene level (P= 0.003, P<0.05), whereas the CD36 protein levels significantly registered an increase (P=0.05, P≤ 0.05). There was an obvious positive correlation between the CD36 gene expression and the OxLDL. In conclusion, a possible effect of anthocyanins contained in H. sabdariffa may have a potential in preventing atherosclerosis evidently rejected by reducing the related biomarkers and regulating the CD36 gene expression in human volunteers. Further evaluation is suggested to examine the effect of pure anthocyanins glucoside in atherosclerosis.
Keywords: CD36 gene expression, Anthocyanins, Atherosclerosis, Bioactive components, Antioxidants, oxidative stress. |
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Supervisor |
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Dr. Heba Abaas Sindi |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1438 AH
2017 AD |
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Co-Supervisor |
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Dr. Mohammed Hussain Al-Qahtani |
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Added Date |
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Wednesday, September 27, 2017 |
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Researchers
| أسماء طلال المالكي | Al Malki, Asmaa Talal | Researcher | Master | |
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