Document Details
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Document Type |
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Thesis |
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Document Title |
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FGF 21 in diabetic individual with and without NAFL disease - relationship to plasma lipids, FFA and insulin sensitivity مستويات FGF21 وعلاقتها بمستوى الدهون و الأحماض الدهنية في الدم و مدى الإحساس والإستجابة للإنسولين لدى مرضى السكري المصابين والغير مصابين بتراكم الدهون في الكبد الذي لا يعود لتناول الكحول |
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Subject |
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Faculty of Medicine |
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Document Language |
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Arabic |
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Abstract |
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Introduction: Non-alcoholic fatty liver disease (NAFLD) is a chronic condition progressing to liver cirrhosis. Diagnosis is based on biopsy, or ultrasound with some serious drawbacks. Non-invasive methods for diagnosis are strongly needed. We Aimed to study the relationship between plasma levels of FGF 21, and plasma lipids, circulating levels of FFA and measures of insulin sensitivity (HOMA- IR, and QUICK), in diabetic individual with and without NAFL to help clarify the physiological roles of FGF21 in the development of NAFL disease.
Subjects and Methods: Type 2 Diabetic (T2DM) patients with & without NAFLD, were recruited from clinics at king Abdul-Aziz University Hospital in case- control design. All patients were screened for NAFLD by using abdominal ultrasound. They were then interviewed to fill a questionnaire for health indices that included medical history of chronic diseases. Height, weight, Waist, hip, and neck circumference (WC, HC, NC), and blood pressure were measured. Biochemical parameters were carried on fasting blood samples.
Results Almost all (98%) of NAFLD patients were overweight or obese, with significantly higher mean weight, WC, HC and NC. Moreover, a significantly higher percentage of above normal SBP & DBP were also noted. Means of liver enzymes, hs-CRP, triglycerides, total and LDL- cholesterol were significantly higher in NAFLD group (p value < 0.05 in all). There were also significant differences in the mean duration of being diabetic (P=0.003). Means of FGF-21, FFA, insulin resistance indices (HOMA-IR, QUICK, revised QUICK) were all higher in the NAFLD group. However, there was overlap in ranges of all variables between the two groups.
Conclusion: It can be suggested that obese, and in particular abdominally obese hypertensive patients with highly increased levels of Triglycerides, AST, GGT, and FGF 21 can be strongly suspected to have NAFLD. |
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Supervisor |
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Prof.Dr.Suhad Bahijri |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1440 AH
2018 AD |
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Co-Supervisor |
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Dr. Ghada Ajabnoor |
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Added Date |
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Wednesday, September 26, 2018 |
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Researchers
| الاء سالم المولد | Al-Mowallad, Alaa | Researcher | Master | |
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