Document Details
|
Document Type |
: |
Thesis |
|
Document Title |
: |
MODULATION OF THE NEURO-TOXICITY INDUCED BY ALUMINUM CHLORIDE IN RATS USING DIFFERENT PLANT EXTRACTS تعديل السمية العصبية المستحثة بكلوريد الألمنيوم في الجرذان باستخدام مستخلصات نباتية مختلفة |
|
Subject |
: |
Faculty of Science |
|
Document Language |
: |
Arabic |
|
Abstract |
: |
The generation of oxidative stress can be referred to aluminum toxic effect in animals and humans. This study aimed to evaluate the role of broccoli (Br) and beetroot (Be) extracts as antioxidant that prevents oxidative stress that associated with aluminum toxicity. Fifty Wistar female rats were grouped into five groups (each 10 rats): Group1: control group, administered drinking water only. Group2: (Neurodegenerative) which was induced by the oral administration of aluminum chloride (20 mg/kg b.w) daily for one month. Group 3: (AlCl3+Ri) rats received aluminum chloride were treated orally with Rivastigmine (1 mg/kg b.w) as a reference drug daily for five weeks. Group 4: (AlCl3+Be) rats received aluminum chloride were treated orally with beetroot extract (50 mg/kg b.w) daily for five weeks. Group 5: (AlCl3+Br) rats received aluminum chloride were treated orally with broccoli extract (50 mg/kg b.w) daily for five weeks.
The obtained results showed a significant (P<0.05) increase in serum aluminum level in AlCl3 group compared to control group. In (AlCl3+Be), (AlCl3+Br) and (AlCl3+Ri) groups showed a significant (P<0.05) decrease in serum aluminum level compared to (AlCl3) group. In (AlCl3) group, showed a significant (P<0.05) decrease in Acetylcholinesterase (AChE), albumin level and GSH level of kidney and increase in Acetylcholine (Ach) level, ALT, AST, uric acid, creatinine and GSH level of liver and (TA) of kidney compared to control. In (AlCl3+Be) group, showed a significant (P<0.05) increase in ALT, protein level and GSH level of liver and decrease in ALP level and GPX level of liver compared to (AlCl3) group. In (AlCl3+Br) group was observed a significant (P<0.05) increase in Acetylcholinesterase (AChE), Norepinephrine (NE) level, ALT level and GSH level of kidney and decrease in ALP, uric acid levels and GPX level of liver and kidney compared to (AlCl3) group. In (AlCl3+Ri) showed a significant (P<0.05) increase in Acetylcholine (Ach), Dopamine (DOP) and Norepinephrine (NE) levels and increase in the ALT level and GSH level of liver and in TA level of kidney and decrease in AST, ALP, protein levels in GPX level in liver and kidney compared to (AlCl3) group. In conclusion, the current data indicated the possible neuroprotective role of broccoli which may result from its antioxidant properties due to its bioactive content such as glucosinolate, isothiocyanate, sulforaphane, and flavonoids. Therefore, broccoli can have a favorable effect on neurotoxicity due to their antioxidant and anti-inflammatory properties. While, betalain in beetroot has been shown it protect cellular components from oxidative injury. |
|
Supervisor |
: |
Prof. Dr. Youssri Mohamed Soliman |
|
Thesis Type |
: |
Master Thesis |
|
Publishing Year |
: |
1440 AH
2019 AD |
|
Co-Supervisor |
: |
Dr. Ashwag Abdullah Albukhari |
|
Added Date |
: |
Thursday, July 11, 2019 |
|
Researchers
| عبير علي البلوي | Albalawi, Abeer Ali | Researcher | Master | |
|
Back To Researches Page
|