Document Details

Document Type : Thesis 
Document Title :
Hepatoprotective Effect of Moringa Oleifera Leaf on Cadmium Chloride Induced Toxicity in Male Rats
التأثير الوقائي الكبدي لأوراق المورينقا أوليفيرا على السمية المستحثة بكلوريد الكادميوم في ذكور الجرذان
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : The fresh matter or extract of different parts of moringa oleifera exhibit antioxidant and protective effects against toxicants and cured several diseases. This study has been conducted to evaluate the hepatoprotective effects of moringa oleifera aqueous extract on cadmium-induced liver toxicity in male albino rats. Thirty-six Wister rats were divided into six groups (n=6). Group I (G I): negative control received only tap water, Group II (G II): received 250 mg/kg b.w. of moringa oleifera aqueous extract, Group III (G III): received 500 mg/kg b.w. of moringa oleifera aqueous extract, Group IV (G IV): received 11mg/kg of cadmium chloride, Group V (G V): received 11mg/kg of cadmium chloride and concurrently treated with 250 mg/kg b.w. of moringa oleifera aqueous extract, Group VI (G VI): received 11mg/kg of cadmium chloride and concurrently treated with 500 mg/kg b.w. of moringa oleifera aqueous extract for four weeks. Cadmium toxicity in G IV increased the levels of serum hepatic marker enzymes as AST, ALT, ALP, GGT and TBIL accompanied by a reduction in serum TP and ALB levels compared with the negative control. Furthermore, hepatic tissues showed a severe damage and the homogenate showed increased MDA content accompanied with decreased SOD, CAT and GSH levels. Administration of moringa in G V and G VI significantly reversed the activities of serum hepatic marker enzymes nearly to their normal levels, reduced lipid peroxidation, increased the antioxidants levels and restored the histological architecture of the liver tissue nearly to normal. In conclusion, moringa oleifera resulted in protecting male rats against cadmium-induced hepatotoxicity by alleviating liver injury as evidenced by the histological and the biochemical examinations. This protecting activity may be ascribed to its content of antioxidant phenolics, β carotene, tannins, saponins, flavonoids, terpenoids and glycosides that scavenge free radicals and protect the liver against the deleterious effect of cadmium intoxication. 
Supervisor : Dr. Fawzia Abdulaziz Alshubaily 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2020 AD 
Added Date : Sunday, June 7, 2020 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
إبتسام سليمان المطيريAlmotairi, Ebtissam SolumanResearcherMaster 

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