Document Details

Document Type : Thesis 
Document Title :
Phytochemical and Biological Studies of Echinops macrochetus
دراسات كيميائية نباتية وبيولوجية على إكينوبس ماكروشيتوس
 
Subject : faculty of Pharmacy 
Document Language : Arabic 
Abstract : Two new rare sesquiterpene glycosides, macrochaetosides A (3) and B (4), together with two known metabolites: stigmasterol (1) and cyclostenol (2) were separated from the CHCl3 fraction of the aerial parts of Echinops macrochaetus Fresen (Asteraceae). Their chemical structures were established on the basis various spectroscopic methods in addition to mass spectrometry and comparison with literature data. Moreover, the cytotoxic activity of these metabolites was assessed towards MCF-7, HepG2, and HCT-116 tumour cell lines using sulphorhodamine B assay (SRB). Compounds 2 and 3 showed a potent cytotoxic profile towards all tested cell lines with IC50s 2.1, 2.9, and 3.6 µM and 1.9, 3.3, and 2.3 µM, respectively. However, 4 exhibited cytotoxic activity against MCF-7 with IC50 6.9 µM. 
Supervisor : Prof. Dr. Hossam Mohamed Abdallah 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2020 AD 
Added Date : Tuesday, June 9, 2020 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
تغريد عبدالجليل زمزميZamzami, Taghreed AbduljaleeResearcherMaster 

Files

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 46339.pdf pdf 

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