Document Details

Document Type : Thesis 
Document Title :
INFLUENCE OF CLAY NANOPARTICLES ON THE EFFECTIVENESS OF DOXORUBICIN AGAINST EHRLICH ASCITES CARCINOMA IN MICE
تأثير جسيمات الطمي متناهية الصغر على فاعلية الدوكسوروبيسين ضد سرطان استسقاء إيرليخ في الفئران
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Cancer is the leading cause of death among people under the age of 85 years. Exploit the unique physical properties of clay nanoparticles make them possessing the unique ability to target cancerous cell and leave healthy cells intact, as well as being less toxic and do not cause harm to living tissue. This research aimed to evaluate hepatoprotective effectiveness of clay nano-formulation in anatagonizing doxorubicin (DOX) cell toxicity effects. One hundrad adult male mice were used. The mice were classified equally to 5 groups. Group 1 (control), Group 2 (EAC group) received a single dose intraperitoneal (IP) injection of 0.15 ml Ehrlich cells (2×106), Group 3 (EAC+DOX group) treated with IP 0.07 ml doxorubicin (10 mg/kg) in six doses equal injections over 2 weeks. Group 4 (EAC+DOX+MMT group) received ip injection of 0.07 ml of doxorubicin loaded on Montmorillonite nanoparticles (MMT) (30 mg/kg) 3 times per week for 2 weeks. Group 5 (EAC+DOX+OCTA+MMT group) received ip 0.07 ml from doxorubicin loaded on Octadecylamine (OCTA) with Montmorillonite nanoparticles 3 times per week for 2 weeks. Blood samples were collected more than 2 times during the experiment. Serum were obtained to measure liver functions. Liver was excised and examined histologically. Serum levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), gamma gutamyl transferase (GGT) and bilirubin were elevated; while albumin and total protein were lower in EAC than control and other groups. Levels of these parameters were improved after treatment of DOX clay nanoparticles. Histological study showed protection against DOX induced degenerative, necrotic and in inflammatory changes in hepatocytes and liver tissues. In conclusion: Clay nanoparticles are effective in DOX delivery system for treatment of Ehrlich-induced ascites carcinoma in mice model. They targeted DOX release to cancer cells and minimized side effect of DOX on liver. 
Supervisor : Dr. Salem Mahmoud Abdullah Mohammed 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2020 AD 
Co-Supervisor : Dr. Abdul Qadir Muhammad Sheikh Omar 
Added Date : Saturday, June 20, 2020 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
منى ابراهيم البوقAlbooq, Mona IbraheemResearcherMaster 

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