Document Details

Document Type : Thesis 
Document Title :
PARKINSON S DISEASE-RELATED BIOMARKERS THAT MAY APPEAR IN AMPHETAMINES ABUSERS
العلامات البيولوجية المتعلقة بمرض باركينسون (الشلل الرعاشي) والتي قد تظهر في مدمني مادة الأمفيتامين
 
Subject : faculty of Applied Medical Sciences 
Document Language : Arabic 
Abstract : Parkinson's disease (PD) is one of the most common neurodegenerative disorders. It is characterized by the degeneration of dopaminergic substantia nigra pars compacta neurons. Amphetamine addiction may cause a serious of psychotic and physical damages to humans. There is some evidence showed that amphetamine may increase the risk of PD. Thus, this study aimed to compare the PD serum biomarkers between amphetamine addicts and PD patients and utilized them as diagnostic biomarkers to early detect of PD incidence among amphetamine addicts. In the current study, seventeen-amphetamine addicts, aged <40 were recruited from Al Amal Psychiatric hospital, Jazan, Saudi Arabia. Nineteen PD patients, and 19 healthy controls, never take amphetamine, were also recruited. Blood samples were withdrawn from all groups. Biomarkers multiplex assay from Milliplex was used to assess the levels of serum amyloid-P (SAP), complement C4, C-reactive protein (CRP) and CRP/albumin ratio in serum samples (Vitros 350® slide was used to assess the albumin). All data were statistically analyzed using one way ANOVA. The results showed that SAP and CRP levels were significantly higher in amphetamine addicts compared to healthy controls (p= 0.0001, p= 0.0001, respectively). The results of amphetamine addicts were comparable to PD levels. However, there are no significant differences between all studied groups concerning complement C4 level. Moreover, albumin levels were significantly decreased and CRP/Albumin ratio levels were significantly increased in amphetamine addicts (p= 0.00 and p= 0.041, respectively) in contrast with controls. These findings indicate that the increased level of these inflammatory biomarkers (SAP and CRP) in the amphetamine addicts may give a potential possibility of their serum level to be used as screening markers to detect PD development in the amphetamine addict. It may be useful to evaluate the changes in easily accessible and cost-effective parameters such as serum CRP/albumin ratio. 
Supervisor : Dr Aziza Al-Rafiah 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2020 AD 
Added Date : Thursday, June 25, 2020 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
محمد محمد الكعبيAl-Kaabi, Mohammed MohammedResearcherMaster 

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