Document Details

Document Type : Thesis 
Document Title :
PREPARATION AND OPTIMIZATION OF ORAL LYOPHILIZED FLASH TABLETS LOADED WITH SILDENAFIL CITRATE SELF NANO-EMULSIFYING SYSTEM
تحضير واستمثال اقراص مجفدة سريعة الذوبان بالفم ومحملة بمستحلب متناهي الصغر لعقار سترات السلدينافيل
 
Subject : faculty of Pharmacy 
Document Language : Arabic 
Abstract : Sildenafil citrate (SLC) is a drug used worldwide mainly to treat erectile dysfunction. Several barriers are facing the conventional product, which decreases its efficacy as; limited solubility, delayed onset of action, low bioavailability with large variability in the absorption profile. The study aimed to develop an optimized SLC self-nanoemulsifying lyophilized tablet (SNELTs) in order to overcome the previously mentioned barriers. The solubility of SLC in various oils, surfactants, and cosurfactants was estimated. Extreme vertices mixture design with a special cubic model was used to develop an optimized SLC-loaded self nanoemulsion with minimum droplet size. Sixteen formulations were prepared and characterized for droplet size. The results of solubility studies indicated that clove oil\oleic acid mixture, Tween 20, and Propylene glycol were selected as oil, surfactant, and cosurfactant, respectively. The optimum SLC-loaded SNEDDS formula showed a droplet size of 65 nm. This formulation is composed of a 10 % oil mixture, 60 % surfactant, and 30 % cosurfactant. For preparation of SNELTs, 0.4% fumed silica, 0.1% HPMC and 0.4% Explotab were the optimum ratio of SNELTs components. This formula is showing satisfactory results in both disintegration and dissolution studies. In vivo pharmacokinetic studies indicated higher bioavailability (1.44 times) for SNELTs compared to conventional tablets. In conclusion, highly bioavailable oral lyophilized flash tablets of SLC was successfully prepared, which will be a good alternative for the conventional solid dosage form. 
Supervisor : Prof. Dr. Khaled Mohamed Hosny Omar 
Thesis Type : Master Thesis 
Publishing Year : 1442 AH
2020 AD 
Co-Supervisor : Dr. Nabil Abdulhafiz Alhakamy 
Added Date : Sunday, January 17, 2021 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
معين عبد العزيز المضواحيAlmodhwahi, Maeen AbdulazizResearcherMaster 

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