Document Details

Document Type : Thesis 
Document Title :
POTENTIAL ANTIFIBROTIC EFFECT OF CERTAIN NATURAL PRODUCT(S) IN EXPERIMENTALLY-INDUCED HEPATIC FIBROSIS IN MICE
التأثير المحتمل لبعض المنتجات الطبيعية المضاد للتليف الكبدي في فئران التجارب
 
Subject : Faculty of medicine 
Document Language : Arabic 
Abstract : Background: Liver fibrosis is a serious health problem worldwide with no successful treatment available in clinical use. Recently, inhibition of pathological angiogenesis was recognized as an effective method to attenuate liver fibrosis. Apigenin is a plant flavone with an excellent safety profile and known antioxidant and anti-inflammatory effects. Lately, apigenin is also identified as a potent antiangiogenic agent that interfered with different signalling molecules in the neovascularization cascade. Objective: To evaluate potential antifibrotic effects of apigenin on carbon tetrachloride (CCl4)-induced liver fibrosis in mice model. Also, to assess the underlying antifibrotic mechanisms with respect to oxidative stress, inflammation, and angiogenesis. Methods: Liver fibrosis was induced using CCl4 injection intraperitoneally (0.5 mg/kg in corn oil 1:4) two times per week. Whereas apigenin was administered orally at two doses (2 and 20 mg/kg) and silymarin was given as a reference agent at (100 mg/kg), three times weekly for 6 weeks. Results and Discussion: CCl4-challenging significantly increased serum aminotransferases activities as well as total cholesterol, triglycerides, and total bilirubin levels. Further, it resulted in significant depletion of liver antioxidation capability and spiked inflammatory response. Notably, CCl4 toxicity caused elevation in angiogenic activities as evident by immunohistochemical (IHC) analysis. On the other hand, apigenin showed improvement in hepatotoxicity markers as well as protection of hepatic architecture and reduction in collagen accumulation. Furthermore, apigenin resulted in significant amelioration of CCl4-induced oxidative stress, inflammation, and angiogenesis. Conclusion: Altogether, these findings support that apigenin possesses a potential antifibrotic effect, which might be attributable to its antioxidant, anti-inflammatory, and antiangiogenic properties. 
Supervisor : Dr. Huda Mohammed Alkreathy 
Thesis Type : Master Thesis 
Publishing Year : 1442 AH
2021 AD 
Co-Supervisor : Dr. Ahmed Esmat Amer 
Added Date : Monday, May 31, 2021 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
مريم عبدالغني مليباريMlibari, Maryam Abdul-GhaniResearcherMaster 

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