Document Details

Document Type : Thesis 
Document Title :
Evaluation of Urolithin, a Pomegranate Metabolite as an Inhibitor of Obesity Driven Endoplasmic Reticulum Stress and Inflammation
تقييم يوروليثين ( ايضة الرمان ) كمثبط لإجهاد الشبكة الاندوبلازمية والإلتهاب الناجم عن السمنة
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Obesity is a metabolic disease characterized by the accumulation of fat in the body. Surprisingly, the prevalence of obesity and its associated co-morbidities is on the increase and no known cure yet. The current pharmacologic interventions are associated with severe side effects and often not suitable for long term use. Therefore, this project aimed to access the potentials of urolithins, the gut microbiota metabolites of ellagitannins and ellagic acid on their ability to attenuate obesity and its associated inflammation and endoplasmic reticulum stress. Animals were divided into four groups with 6 rats per group. Control rats were maintained on a chow diet and the other three groups were fed on a high-fat diet until they develop obesity and thereafter treated with urolithin A and B. The animals fed on a high-fat diet gained more weight, developed hepatic ER stress, and hypothyroidism. However, treatment with urolithin A and B decreased body weight gain, reduced hepatic ER stress and restored triiodothyronine level. Urolithin A effect on inflammation is cytokine-dependent. Treatment with urolithin A and B showed hepatoprotective potentials through their ability to restore hepatic levels of AST and ALT. The results of this study showed the potential anti-obesity effect of urolithin A and B. These results revealed that these metabolites reduced body weight, protect against liver damage, and improved metabolic function. It also showed that both urolithin A and B have the potential to reduced hepatic ER stress. 
Supervisor : Dr. Wesam H. Abdulaal 
Thesis Type : Master Thesis 
Publishing Year : 1442 AH
2021 AD 
Co-Supervisor : Dr. Mustafa Zeyadi 
Added Date : Wednesday, June 23, 2021 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
زهير أحمد الشهريAlshehri, Zuhair AhmedResearcherMaster 

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