Document Details
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Document Type |
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Thesis |
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Document Title |
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STUDIES ON THE POTENTIAL INHIBITORY AND PROTECTIVE ROLE OF HONEYBEE PRODUCTS AGAINST THE CYTOLOGICAL AND CYTOGENETIC EFFECTS OF 5-FLUOROURACIL دراساتٍ على الدورِ التثبيطيِّ والوقائيِّ المُحتمل لمُنتجات نحلِ العسلِ ضدَّ التأثيراتِ الخلويةِ والوراثيةِ الخلويةِ لعقارِ 5- فلورويوراسيل |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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The present study aims to evaluate the potential therapeutic effect of different treatments of bee products with curative properties and compare treatment with 5-fluorouracil as one of the drugs used in the treatment of many carcinomas outside the body of the organism (in vitro), and to evaluate the potential protective effect of treatment with bee products against cytogenetics effects in the bone marrow cells of male albino mice (biologically) as a result of treatment with 5-fluorouracil. To achieve the first goal, colon cancer cell lines HCT-116, breast cancer MCF-7, and live cancer cell line HepG2 were used, and they were divided into ten main groups: first: the control group, second: the treatment with the drug, third: royal jelly , fourth: royal jelly with the drug, fifth: honey, sixth: honey with the drug, seventh: bee grains, eighth: bee grains with the drug, ninth: mixture of bee products, the tenth: mixture of bee products with the drug at concentrations 0.1, 1.0, 10, 100, 1000 µg/ ml for an incubation period of 72 hours, and the results were revealed Cellular: Firstly: the ability of bee products to inhibit different cancer cells in varying proportions. Second: the double treatment of bee products with the drug had higher rates of inhibition than the single treatment with the drug. The results depended on the concentration and the type of cancer cells .To achieve the second goal, 50 male mice were used, divided into ten main groups: first: the control group, second: the drug treatment, third: royal jelly , fourth: honey, fifth: bee grains, sixth: mixture of bee products, Seventh: royal jelly with the drug, eighth: bee grains with the drug, ninth: mixture of bee products, tenth: mixture of bee products with the drug, and the results of cytogenetic examination in the second group of drug treatment showed an increase in the number of chromosomal abnormalities in the cells bone marrow, when combined with bee products, showed a decrease in the number of chromosomal abnormalities, so the current study recommends the use of bee products when chemotherapy is a preventive or adjunctive treatment as a complement to anti-cancer treatments. |
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Supervisor |
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Prof.Lina Abdul-fattah Kurdi |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1442 AH
2021 AD |
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Added Date |
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Monday, September 6, 2021 |
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Researchers
| فاطمة سعد الحصيني | Alhusayni, Fatimah Saad | Researcher | Doctorate | |
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