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Document Type |
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Thesis |
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Document Title |
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EFFECT OF SOY ISOFLAVONES ON THE PERFORMANCE OF CEREBRAL NEUROTRANSMITTER SYSTEMS IN ADULT AND AGED MALE RATS تأثير ايزوفلافونات الصويا على أداء أنظمة النواقل العصبية الدماغية في جرذان الذكور البالغة والمسنة |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Isoflavones are polyphenolic compounds that are capable of exerting estrogen-like effects. For this reason, they are classified as phytoestrogens plant-derived compounds with estrogenic activity. Neurotransmitters are endogenous chemical that enable neurotransmission. It is a type of chemical messenger that transmits signals across a chemical synapse, such as a neuromuscular junction, from one neuron to another neuron, muscle cell, or gland cell. Soy has been consumed as a traditional food in Asia for a long time. Soy contains numerous phytochemicals including isoflavones, phytic acid, trypsin inhibitors and saponins. This study aims to Investigate the effect of Soy isoflavones on the performance of neurotransmitter systems in adult and aged male rats and compare between the changes induced by Soy isoflavone in the brain biochemistry and histopathology. Methodology: Forty rats were randomized into four equal groups as follow: G1 Adult control group; rats fed on basal diet (Adult-C) G2 Aged control group; rats fed on basal diet (Aged-C). G3 Adult Isoflavone group (Adult-Iso); rats fed on basal diet and received isoflavone (100 mg /Kg body wt) dissolved in distilled water by oral gavage; G4 Aged Isoflavone group (Aged-Iso); rats fed on basal diet and received isoflavone (100 mg /kg body wt) dissolved in distilled water by oral gavage. At the end of experiment (4 weeks) blood samples were collected for biochemical parameters, Brains were excised for histopathological and macroscopic examination. Result: Current evidence revealed that, soy isoflavones treated groups showed enhancement in dopamine, serotonin, norepinephrine, nitric oxide, acetylcholine, glutamate and GABA whereas decrease in choline acetyl transferase. Examination of sections obtained from brains of the aged isoflavone treated group showed markedly better histological structure. Conclusion: Soy isoflavones improved the neurotransmitters and brain cells functionally and lead to improve the cognitive functions in Aged groups. |
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Supervisor |
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Prof. Fares Khairy Khalifa |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1443 AH
2022 AD |
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Co-Supervisor |
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Dr. Mustafa Adnan Zeyadi |
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Added Date |
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Saturday, March 19, 2022 |
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Researchers
| محمد عوض الحازمي | Alhazmi, Mohammed Awad | Researcher | Master | |
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