Document Details
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Document Type |
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Thesis |
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Document Title |
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Evaluation of Renal Protective Effects of Lyophilized Kiwifruit Extract on Toxicity of Glycerol in Male Rats تقييم التـأثيرات الوقائية الكلوية لمستخلص فاكهة الكيوي المجفف بالتجميد على سمية الجلسرين في ذكور الجرذان |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Owing to the possible side effects of some therapeutic agents, natural products such as fruits and herbs have recently been used to prevent the incidence of renal damage. Kiwifruit is renowned for its antioxidant qualities and polyphenol content. Acute kidney injury (AKI) is a common clinical problem in Saudi Arabia. The study aimed to evaluate and compare the protective effects of alcoholic and aqueous extracts of lyophilized kiwifruit on AKI induced by glycerol in male albino rats. Rats were divided into six groups: negative control healthy group, AKI rats group induced by glycerol injection as a dose 10ml/kg after 24-h water deprivation, healthy rats group administered with ethanolic kiwifruit extract doses 5ml/kg, healthy rats group administered with aqueous kiwifruit extract doses 5ml/kg, AKI rats group treated with ethanolic kiwifruit extract doses 5ml/kg, and AKI rats group treated with aqueous kiwifruit extract doses 5ml/kg. Kidney biomarkers, oxidative stress, and inflammatory markers were measured and histological examination was performed. We observed that glycerol induced AKI and as a result there was an increase in the levels of blood urea nitrogen, creatinine, sodium, potassium, chloride, uric acid, cystatin-C, C-reactive protein, tumour necrosis factor-α, neutrophil gelatinase-associated lipocalin, interleukin-6, malondialdehyde, white blood cells and, platelet as well as a decrease in the levels of glutathione, superoxide-dismutase, red blood cells and, hemoglobin compared to that in the negative control group. Ethanolic and aqueous kiwifruit extracts improved all the kidney biomarkers in AKI rats. Histological examination showed acute tubular necrosis in the AKI group. However, there was an improvement in the renal tissue, represented by epithelial cell regeneration, in rats that were administered both the extracts. Based on findings, it can be concluded that kiwifruit extracts have a positive effect on serum biochemical parameters and renal tissue, which can be beneficial in the treatment of AKI. The treatment with the ethanolic extract is more potent than with the aqueous extract. |
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Supervisor |
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Dr. Fares Khalifa |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1443 AH
2022 AD |
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Added Date |
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Thursday, January 19, 2023 |
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Researchers
| راوية محمد حكمي | Hakami, Rawiyah Mohammed | Researcher | Master | |
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