Document Details

Document Type : Thesis 
Document Title :
Studies on the gut-skin axis microbiome of eczema patients
دراسات على محور ميكروبيوم القناة الهضمية-الجلد لمرضى الإكزيما
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Microbiome is the new organ of the body. The microbiome and especially the Gut Microbiome is very important to be studied and thoroughly investigated to better understand the correlation between Microbiome and human health and Diseases. In this study, 12 children, 6 Atopic Dermatitis (AD) patients and 6 were control (CO), were involved to search for a potential explanation of the AD development through differences that may be spotted between their gut microbiome. In this study 12 children were included, 6 of them are AD patients and the other 6 are healthy control participants; the age group is between 2 to 7 years old. A fecal sample was collected and preserved for Deoxyribonucleic Acid (DNA) extraction from each sample. After DNA extraction, 16S Ribosomal Ribonucleic Acid (rRNA) (V3 – V4 region) were multiplied by Polymerase Chain Reaction (PCR) and sent to Beijing Genome Institution (BGI) for Sequencing and Bioinformatics. Once the result was received a data analysis was performed. Data statistics showed a slightly fluctuated result for each sample. The operational Taxonomic Unite (OUT) presented 371 Bacteria and the top three most abundant phyla for both groups were Bacteroidetes, Firmicutes, and Proteobacteria. However, on a phyla level AD group has shown a distinguish bacteria as a biomarker which is Streptococcaceae. 
Supervisor : Dr. Rashad al-Hindi 
Thesis Type : Doctorate Thesis 
Publishing Year : 1443 AH
2022 AD 
Added Date : Wednesday, January 25, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
هيثم عبدالرحمن الغامديAlghamdi, Hitham AbduarhmanResearcherDoctorate 

Files

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 48910.pdf pdf 

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