Document Details
|
Document Type |
: |
Thesis |
|
Document Title |
: |
Synthesis and Molecular Modeling for Biological Approach for Some Drug-Based Metal Complexes تحضير ونمذجة جزيئية للتطبيقات البيولوجية لبعض معقدات الفلزات مع بعض المركبات الدوائية |
|
Subject |
: |
Faculty of Science |
|
Document Language |
: |
Arabic |
|
Abstract |
: |
The imidazole-based complexes were prepared by the reaction of some transition metals (Cu(II), Zn(II), Ni(II),Co(II),Mn(II)) in form of MCl2.nH2O with the imidazole-based drugs (Clotrimazole CTZ, miconazole MCNZ, Pantoprazole PPZ). The metal complexes were characterized by analytical and spectroscopic techniques: elemental analysis, infrared spectroscopy IR, UV-Vis spectroscopy, Electron paramagnetic resonance spectroscopy EPR, Thermographic analysis TGA, and kinetic study of metal complexes. The final structures were in the form of [M(CTZ)2(H2O)2Cl2], [M(MCNZ)2(H2O)2Cl2], and [M(PPZ)2Cl2] where: [M= Cu, Zn, Ni, Co, Mn]. Biological study of the complexes includes DNA binding with CT-DNA, the complexes found to be intercalation binders to the DNA. The molecular docking with 1TUB protein score were in the range -9.36 to -4.77 the highest scores were found for the [Cu(CTZ)2(H2O)2Cl2], [Cu(MCNZ)2(H2O)2Cl2], and [Cu(PPZ)2Cl2] respectively. The Cu complexes have the highest anticancer activity against M-14. |
|
Supervisor |
: |
Dr. Amal Salimin Saleh |
|
Thesis Type |
: |
Master Thesis |
|
Publishing Year |
: |
1443 AH
2022 AD |
|
Added Date |
: |
Saturday, January 28, 2023 |
|
Researchers
| نجود سالم الشهري | AL-Shehri, Nujud Salem | Researcher | Master | |
|
Back To Researches Page
|