Document Details
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Document Type |
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Thesis |
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Document Title |
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EXPLORING THE ASSOCIATION BETWEEN SKIN AUTOFLUORESCENCE AND OBSTRUCTIVE SLEEP APNOEA IN SAUDI ARABIAN ADULTS دراسة العلاقة بين قياس الوميض الطيفي الذاتي لسطح الجلد وتوقف التنفس أثناء النوم لدى البالغين في المملكة العربية السعودية |
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Subject |
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Faculty of medicine |
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Document Language |
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Arabic |
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Abstract |
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Introduction: Obstructive Sleep Apnoea (OSA) is caused by repeated temporary restriction to the airways during sleeping and is associated with a variety of symptoms ranging from snoring, daytime fatigue and sleepiness. OSA is considered the most popular sleep-related breathing disorder; most common in old age males, and may also affect children and women. Polysomnography (PSG) is used to diagnose OSA but it is difficult, time consuming and expensive. Accumulation of advanced glycation endproducts (AGEs) has been implicated in OSA. Non-invasive measurement of skin autofluorescence (SAF) severs as a proxy of tissue accumulation of AGEs. The aim of the study was to establish whether (SAF), which indicates AGEs accumulation in the forearm, could serve as a non-invasive tool and biomarker of OSA in Saudi patients.
Methodology: One hundred and sixty undiagnosed Saudi subjects (18-80 years) attending the Sleep Medicine Unit at KAU Hospital were recruited for the study. After investigation and PSG tests in the unit 137 participants were diagnosed as OSA (patients) and 23 as non OSA and therefore considered as control for the study. SAF measurement of all study participants using an AGEs reader, then PSG test were done. Data about demography, anthropometry, lifestyle, disease and family history of diseases were collected. Statistical analysis to determine the association between SAF and OSA was conducted.
Results: The study showed that the mean AGEs in the OSA patient group was 47.0 ± 1.2 years (mean ± SE) compared to 37.2 ± 2.5 years in control. Also, the mean weight and body mass index (BMI) of the OSA group was 105.8 ± 2.8 Kg and 41.2 ± 1.3 compared to 82.1 ± 4.3 Kg and 30.9 ± 1.6. in the control group respectively. Moreover, the mean of cigarette smoking was more than double in the case of the OSA patients (17.9 ± 2.1 cigarette\day) as compared to the control group (6.7 ± 1.7). Skin Autofluorescence Value of OSA Patients was 2.30 ± 0.05 as compared to 1.89 ± 0.13 in the control group. SAF value for the AGEs group (36 – 45 yrs) was significantly higher than the AGEs group (more than 55 yrs). In addition, SAF Value of patients increased with duration of smoking in OSA group from 1.85 ± 0.16 to 2.64 ± 0.15.
Conclusion: our study has demonstrated that marked higher SAF values were observed in the OSA patients which can be used as a potential and non-invasive tool and key marker for the diagnosis of OSA. Also, risk factors like old AGEs, obesity, smoking cigarettes, smoking Shisha (Hookah), smoking duration, high BMI, and lack of exercise has demonstrated that directly correlate with a higher incidence of OSA.
Keywords: skin autofluorescence, advanced glycation endproducts, Obstructive Sleep Apnoea, Polysomnography, Smoking duration. |
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Supervisor |
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Dr. Zuhair Damanhouri |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1444 AH
2022 AD |
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Added Date |
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Monday, February 27, 2023 |
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Researchers
| سلطان منيف الدلبحي | Sultan, Munif Al-Dalbhi | Researcher | Master | |
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