Document Details

Document Type : Thesis 
Document Title :
Possible Correction of High Fat Altered Metabolome by Urolithin’s
التصحيح المحتمل لمستقلب الأيض المعدل عالي الدهون بواسطة Urolithin’s
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Obesity and overweight are worldwide public health concerns. Although governments seek for obesity solutions, rates are at alarming percentages. One of the major interrelated health outcomes of obesity is non-alcoholic fatty liver disease (NAFLD). The gut microbiota consists of a community of microorganisms that inhabit the large intestine. These microbes play important roles in maintaining gut barrier integrity, inflammation, lipid and carbohydrate metabolism, immunity, and protection against pathogens. However, recent studies have shown that dysfunction in the gut microbiota composition can lead to the development of several diseases. Urolithin A has recently been approved as a functional food ingredient. This project aims to explore the possible anti-obesity mechanism of urolithin A as well as assessing the impact of urolithin A on high fat driven lipogenesis. In this project, the potentials of urolithin A (Uro-A) and B (Uro-B) in improving metabolic functions and their impact on gut microbiota composition under a metabolically unchallenged state in normal rats have been examined. Male Wistar rats (n = 18) were randomly segregated into three groups, with Group 1 serving as the control group. Groups 2 and 3 were administered with 2.5 mg/kg Uro-A and Uro-B, respectively, for four weeks. Results showed that both Uro-A and B improved liver and kidney functions without affecting body weight. Metagenomic analysis revealed that both Uro-A and B induced the growth of Akkermansia. However, Uro-A decreased species diversity and microbial richness and negatively impacted the composition of pathogenic microbes in normal rats. Taken together, this study showed the differential impacts of Uro-A and B on the gut microbiota composition in normal rats and would thus serve as a guide in the choice of these metabolites as a functional food ingredient or prebiotic. 
Supervisor : Dr. Mohammad Imran Khan 
Thesis Type : Doctorate Thesis 
Publishing Year : 1444 AH
2022 AD 
Added Date : Monday, February 27, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
علي خلف الخلفAl Khalaf, Ali KhalafResearcherDoctorate 

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