Document Details
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Document Type |
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Thesis |
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Document Title |
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EFFECT OF ASTAXANTHIN ON EXPERIMENTALY-INDUCD DIABETIC KIDNEY DISEASE تأثير الأستازانثين على نموذج تجريبي لاعتلال الكلى السكري |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Background: Diabetes mellitus is a highly increasing worldwide health issue. Diabetic kidney disease is one of the highly recurrent consequences of diabetes, where it is considered the pivotal reason for end stage renal disease. Some peptides of the renin angiotensin system, such as angiotensin-II, are crucial pathologic factors in diabetic kidney disease, whereas others, such as angiotensin 1-7, have renal therapeutic potentials. Astaxanthin, a natural aquatic product, was shown to be safe in animals and humans, and effective in various diseases. The impact of astaxanthin on diabetic kidney disease has not been clearly elucidated.
Objective: To investigate the reno-protective effect of an eight-week astaxanthin treatment in streptozotocin-induced diabetic rats and its related mechanisms.
Methods: Streptozotocin (45 mg/kg intraperitoneally) was used for diabetes induction. Control, diabetes, diabetes and ramipril, diabetes and astaxanthin (10 or 50 mg/kg orally), and astaxanthin (50 mg/kg orally) were the study groups of male Wistar rats. Diabetes was assessed by measuring fasting blood glucose levels, and the diabetic symptoms, while kidney disease by serum creatinine, urinary albumin, and urinary cystatin C levels. Angiotensin converting enzyme 1 and 2, angiotensin 1-7, and neprilysin were measured in kidney homogenates. Histopathological evaluation was also performed.
Results & Discussion: Diabetic symptoms, serum creatinine, and urinary albumin and cystatin C levels were attenuated by astaxanthin, while angiotensin 1-7 level was elevated. Astaxanthin reduced angiotensin converting enzyme 1 activity, while increased angiotensin converting enzyme 2 and neprilysin activities. Besides, hyperlipidemia, inflammatory parameters, kidney structural abnormalities, and collagen accumulation were attenuated. In previous research the antioxidant, antiapoptotic, anti-inflammatory, and antifibrotic effects of astaxanthin were confirmed. Also, correlations between the renin angiotensin system and oxidative stress, apoptotic, inflammatory, and fibrotic pathways were identified. Therefore, astaxanthin’s reno-protective effect in diabetic kidney disease could be due to modulation of the renin angiotensin system decreasing the previous pathways.
Conclusion: This study was the first to uncover that astaxanthin could protect against diabetic kidney disease by enhancing the protective elements of the renin angiotensin system and reducing urinary cystatin C level. Clinical research on astaxanthin in diabetic kidney disease are encouraged.
Keywords: Renin, angiotensin, astaxanthin, diabetes, kidney. |
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Supervisor |
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Dr. Huda Al-Kuraithi |
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Thesis Type |
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Doctorate Thesis |
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Publishing Year |
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1444 AH
2022 AD |
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Added Date |
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Monday, February 27, 2023 |
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Researchers
| يسرى صالح أنديجاني | Andijani, Yusra Salih | Researcher | Doctorate | |
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