|
Document Type |
: |
Thesis |
|
Document Title |
: |
Synthesis and biological activity of new pyrazoline derivatives التشييد والنشاط البيلوجي لمشتقات البيرازولين الجديدة |
|
Subject |
: |
Faculty of Science |
|
Document Language |
: |
Arabic |
|
Abstract |
: |
This research aims to synthesize and characterize three series of new pyrazoline compounds and study their biological activities, three new series of pyrazoline derivatives have been prepared in good yield. These compounds were synthesized by Claisen-Schmidt condensation of aminoacetophenone and four different aryl aldehydes to give chalcones (1a-d). Preparing pyrazoline compounds (2a,b, and 3a-d) with two different methods to form the newly fabricated N-acyl pyrazoline (2a,b) compounds by cycloaddition of hydrazine hydrate with chalcones (1a,b) in presence of trifluoroacetic acid, and cycloaddition of thiosemicarbazide with chalcones (1a-d) to offer pyrazolinyl carbothiamide (3a-d). Finally, the Hantzsch cyclization reaction of pyrazoline derivatives (3a-d) with two different methods to allow producing hybrid pyrazoline-thiazole (4a-d and 5a-d) compounds. Different spectral analyses were performed on all synthesized compounds to elucidate and confirm their structures (IR, 1H NMR, 13C NMR, and LC-MS/MS). The pyrazoline derivatives (2a,b, 4a-d, and 5a-d) synthesized in this thesis revealed no or weak antimicrobial activity as per the evaluation made in this study.
Keywords: (Chalcones, N-acyl pyrazoline, Bi-heterocyclic, Pyrazoline-thiazole, Pyrazoline-thiazolidinone) |
|
Supervisor |
: |
Dr. Zahra Alamshany |
|
Thesis Type |
: |
Master Thesis |
|
Publishing Year |
: |
1444 AH
2023 AD |
|
Co-Supervisor |
: |
Dr. Nada Tashkandi |
|
Added Date |
: |
Monday, May 1, 2023 |
|
Researchers
| أمجاد علي الحلكي | Alhalki, Amjad Ali | Researcher | Master | |
|