Document Details

Document Type : Thesis 
Document Title :
THE POTENTIAL IMPACT OF VITAMIN D SUPPLEMENTATIONS ON OXYTOCIN (OXT) GENE EXPRESSION IN SAUDI AUTISTIC CHILDREN.
إمكانية تأثير مكملات فيتامين د على التعبير الجيني للاوكسيتوسين (OXT) في أطفال التوحد السعوديين
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Autism spectrum disorder (ASD) is a complicated neurodevelopmental disorder resulting from a combination of genetic, epigenetic, and environmental factors. Previous research has found that ASD is linked to brain development that affects socializing with others, resulting in issues with social interaction and repetitive behavior patterns. According to the Saudi Ministry of Health, one out of every 160 children was diagnosed with an autism spectrum disorder. One of the most important environmental factors to consider is vitamin D deficiency. It is the most common nutritional disorder in the world and there is increasing evidence indicating that vitamin D deficiency is associated with neurodevelopmental disorders including autism and schizophrenia. Vitamin D deficiency may contribute to the severity of ASD symptoms and appears to be significant in the etiology of ASD by affecting the production of oxytocin that mediates the expression of the OXT gene. This study showed a direct relationship between vitamin D levels and OXT expression levels in ASD children. Most children with autism have vitamin D deficiency, as well as downregulated OXT expression of most samples, before supplements. After using the supplements, an increase in vitamin D was observed, which led to an increase in OXT expression in the majority of the samples and an improvement in children's symptoms. These findings support the hypothesis that deficiency of vitamin D could be related to the downregulation of OXT gene expression and then might be associated with ASD. This study aims to investigate vitamin D supplements' impact on the OXT gene expression of Saudi autistic children. 
Supervisor : Dr. Sheren Azhri 
Thesis Type : Master Thesis 
Publishing Year : 1445 AH
2023 AD 
Co-Supervisor : Dr. Reem Farsi 
Added Date : Saturday, September 16, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
بتول عبدالله بايوسفBayusuf, Batool AbdullahResearcherMaster 

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