Document Details

Document Type : Thesis 
Document Title :
The Therapeutic Effect of Clubmoss (Lycopodium) and Ashwagandha (Withania Somnifera) on Alzheimer’s Disease Induced by Aluminum Chloride in Rats
التأثير العلاجي لنبات رجل الذئب والأشواغاندا على مرض الزهايمر المستحث بكلوريد الألمنيوم في الجرذان
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Alzheimer’s disease (AD) is a serious health problem worldwide and it is the main cause of dementia. Unfortunately, there is no known cure for this disease. In recent few decades, researchers have started to pay attention to natural plants as an alternative therapy for AD not only to enhance brain functions but also avoid neurodegeneration. lycopodium (Lyc) and Withania somnifera (WS) are two herbs with antioxidant and anti-inflammatory properties that have been shown to enhance cognitive and brain function. The study was carried out to investigated the effect of oral administration of Lyc or/and WS on AD rats induced by AlCl3. Fifty female rats have divided into five groups: control, AD rats (175mg of AlCl3/kg/day for 30 days), AD rats treated with Lyc (50mg/kg/day), AD rats administered with WS (200mg/kg/day), and AD rats administered with their combination by gastric intubation for 4 weeks. After 30 days rats were subjected to a Y maze test to assess short term memory. Moreover, serum SOD, CAT and inflammatory markers (TNF-, IL-1 and IL-6) and brain GSH, MDA, NO, cholinergic enzymes (Ach, AchE, BchE), TH, Na+/K+ ATPase and A-42 have been estimated at the end of the experiment. The results showed a decrease in memory of AD group compared to the treatments groups as revealed in Y maze test by increase number of entries arms. Significant increase levels of cholinergic enzymes, lipid peroxidation, and inflammatory markers accompanied by a significant decrease in antioxidants enzymes were observed in AD rats compared to control group. Treatment of AD rats with Lyc or/and WS for 30 days has ameliorated the damage caused by AlCl 3 associated with the improvement of behavioral and biochemical changes in comparison to AD rats' group. A combination of both Lyc and WS extracts exhibited more amelioration than these extracts alone and reversed the adverse effect of AlCl3 in rats by bringing biochemical analyses near to that of control. This study suggested that oral administration of Lyc and WS had neuroprotective effects by improving learning and memory in AD rats’ models. This effect is due to ability of WS and Lyc to eliminate free radicals and reduced oxidative stress which restore brain functions of AD. 
Supervisor : Prof. Dr. Nadia Nour Osman 
Thesis Type : Master Thesis 
Publishing Year : 1445 AH
2023 AD 
Co-Supervisor : Dr. Rasha Abdulrasheed Mansouri 
Added Date : Tuesday, October 3, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
فضه عبدالله العتيبيAlotaibi, Foddah AbdullahResearcherMaster 

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