Document Details
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Document Type |
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Thesis |
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Document Title |
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Study on the Efficacy of Single Clove Garlic (Allium sativum) Against Cadmium Toxicity on Some Physiological and Histological Aspects, in Rats دراسة فعالية الثوم الذكر (( Allium sativum ضد سمية الكادميوم على بعض النواحي الفسيولوجية والنسيجية في الجرذان |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Background: Cadmium (Cd) is widespread pollutant that affectes human health.Objective: The present study aimed to investigate the possible protective effect of garlic extract(Allium sativum) on the toxicity of oral administration of cadmium for 4 weeks on adult rats. Methods: 32 adult male rats were used and divided equally into four groups each with 8 rats:Group I: Control group, the rats of this group were given normal diet and water for four weeks,Group II: Garlic group, the rats of this group received garlic extract 350 mg/kg bw by stomachtube every second day for four weeks, Group III: Cadmium group, the rats of this group received 60 mg/kg bw Cadmium by stomach tube every second day for four weeks, and GroupIV: Garlic + Cadmium group, the rats of this group received garlic extract 350 mg/kg bw then60 mg/kg bw Cadmium by stomach tube every second day for four weeks. At the end of the experiment, samples of blood were taken for biochemical analysis. Then rats were sacrificed and dissected, and samples of liver and kidney were collected for histological studies. Body weight was measured at the beginning and the end of the experiment. Blood samples were collected at experiment end. Sera prepared to measure activities of liver and kidney functions. Results: It was observed that weight gain was significantly decreased in Cd group and Garlic +Cd group versus control and Garlic groups. Percentage changes in body weight were significantly decreased in Cd group and Garlic + Cd group versus control and Garlic groups. Cadmium administration caused significant increases in the activities of ALT, AST and ALP enzymes, and in the values of CRE, URE, UA, TG, CHOL, LDL-c and VLDL-c, but HDL-c was significantly decreased. These changes were ameliorated with administration of garlic. Conclusions: Cadmium administration produces toxic effects that partially improved after garlic administration due to its antioxidant and anti-inflammatory effects.
Keywords: Cadmium, Garlic, Liver, Kidney, Protective effects, Physiology, Histology, rats. |
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Supervisor |
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Dr. Moustafa Hussein Elnaggar |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1445 AH
2023 AD |
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Co-Supervisor |
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Prof. Mansour Attiah Alhazmi |
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Added Date |
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Sunday, October 15, 2023 |
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Researchers
| نورة محمد الميموني | Almaimouni, Noura Mohammed | Researcher | Master | |
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