Document Details

Document Type : Thesis 
Document Title :
Exploration of potential Anti-neo plastic activities of urolithins in leukemia cancer cells
دراسة أنشطة اليوروليثيات المحتملة المضادة للأورام في خلايا سرطان الدم النخاعي الحاد
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Leukemia is persisting in being a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic acid and ellagitannins containing pomegranate and walnuts. Here, we assessed the potential antileukemic activities of both urolithin A and urolithin B. Results showed that both urolithin A and B significantly inhibited the proliferation of leukemic cell lines Jurkat and K562, among which Urolithin A showed the more prominent anti-proliferative capability. Further, urolithin treatment alters leukemic cell metabolism, as evidence by increased metabolic rate and notable changes in glutamine metabolism, one-carbon metabolism, and lipid metabolism. Next, we evidenced that both urolithins were equally promoting apoptosis in leukemic cell lines. Based on these observations, we concluded that both urolithin A and B alter leukemic cell metabolome, resulting in a halt of proliferation, followed by apoptosis. The data can be used for designing new combinational therapies to eradicate leukemic cells. 
Supervisor : Dr. Abrar Ahmad Moinuddin 
Thesis Type : Master Thesis 
Publishing Year : 1445 AH
2023 AD 
Added Date : Wednesday, October 25, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبدالعزيز موسى الزهرانيAlzahrani, Abdulaziz MusaResearcherMaster 

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 49423.pdf pdf 

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