Document Details

Document Type : Thesis 
Document Title :
Serological investigation for Hepatitis E Virus infection in some regions of the Kingdom of Saudi Arabia
الاستقصاء المصلي لعدوى فيروس التهاب الكبد (ي) في بعض مناطق المملكة العربية السعودية
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Hepatitis E virus (HEV) infection is a common enterically-transmitted disease in developing countries. During the last decade, the sporadic occurrence of hepatitis E has also increased in developed nations. However, these cases vary from developing countries because of zoonotic transmission. HEV RNA and IgM antibodies are commonly employed to detect acute (current) infection whereas IgG antibodies are used to detect previous infections. HEV RNA in the sample represents the current infection (chronic or acute). There are one serotype and eight genotypes of HEV. Genotypes 1 and 2 specifically infect humans. These are mainly caused by HEV genotype 1 or 2 through contaminated drinking water and fecal–oral transmission. Materno-fetal (vertical spread), contaminated food, and parenteral routes are less frequent. Contaminated food probably serves as a source of zoonotic HEV infection in humans. The current study investigates the HEV seroprevalence in the two cities of Medina and Jizan. HEV-LP ELISA assay was conducted to test the serum samples for anti-HEV-IgG antibodies. This study showed an overall anti-HEV-IgG seroprevalence in Medina to be slightly higher (27.6%) than Jizan (25.5%) with no significant difference. The seroprevalence was found to be higher in males (61.9%) compared to females (38.1%). Its prevalence was noted to be high among 21 to 30 years old individuals (24.3%). The only clinical manifestation that showed correlation with the seroprevalence was diabetes with a p value of <0.001. other clinical manifestations like fever, headache, joint pain, vomiting, skin rash, liver or kidney diseases did not show a statistically significant correlation. Neither visiting a healthcare facility nor hospitalization showed significant correlation with HEV seroprevalence. Key words: HEV; Saudi Arabia; General population; Seroprevalence 
Supervisor : Dr. Sari S. Sabban 
Thesis Type : Master Thesis 
Publishing Year : 1445 AH
2023 AD 
Co-Supervisor : Prof. Sherif A. El-Kafrawy 
Added Date : Tuesday, October 31, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
مصطفى محمد الشودريALSHAWADRI, MUSTAFA MohammedResearcherMaster 

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