Document Details
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Document Type |
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Thesis |
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Document Title |
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Prevalence and Distribution of Multidrug-Resistant Klebsiella Pneumoniae Infection in the Intensive Care Unit of Aseer Central Hospital انتشار وتوزيع عدوي الكلبسيلا الرئوية المقاومة للمضادات الحيوية في وحدة العناية المركزة بمستشفى عسير المركزي |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Klebsiella pneumoniae is a common opportunistic pathogen and is considered the main cause of nosocomial infections. This species harbors the carbapenem-resistant gene thus creating challenges for infection and is attracting significant attention due to its global rapid dissemination. Up to date, little data regarding the prevalence and trends of K. pneumoniae in Saudi Arabia in general and in Aseer area. The objective of the current study was to address the possibility of antibiotics resistant to K. pneumoniae infection and to identify the risk factors associated with their multidrug resistance. Various clinical samples were collected from 264 K. pneumoniae suspected registered to different units of Aseer Central Hospital and were processed for K. pneumoniae isolation using selective culture media. The positive isolates were further analyzed for the presence of drug resistance and the virulence genes. Different bacteria were detected in 158 (59.8%) samples. Comparatively, the bacterial isolates were significantly higher in female than in male (P=0.026). More than 78% of bacteria were resistant to the tested antibiotics. Resistance rates of 100%, 96.9%, 94.5%, 87.1%, and 83.6% were recorded against, gentamicin, levofloxacin, amikacin, minocycline, and norfloxacin, respectively. Total 23 (8.7%) specimens were tested positive for target genes namely, blaNDM1 (n=7) and bla OXA48 (n=16). These detected gene was lower than those previously reported elsewhere. This study may provide the necessary information to formulate a hospital antibiotic policy and prevent the spread of multidrug-resistant strains in the community. In addition, reducing the disease burden using integrated broad-spectrum antibiotics in conjunction with susceptibility tests is highly recommended.
Keywords: K. Pneumoniae, Infections, Prevalence, Distribution, Resistance, Multiple Drugs, Intensive Care Units |
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Supervisor |
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Prof. Mohamed Morsi Ahmed |
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Thesis Type |
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Doctorate Thesis |
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Publishing Year |
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1445 AH
2023 AD |
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Co-Supervisor |
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Dr. Atif Abdulraheem Bamagoos |
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Added Date |
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Wednesday, November 1, 2023 |
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Researchers
| خالد علي خزيم | Khuzim, Khaled Ali | Researcher | Doctorate | |
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