Document Details
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Document Type |
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Thesis |
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Document Title |
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ANTIOXIDANT ACTIVITY AND INHIBITORY EFFECT OF 2 4 4 -TRIHYDROXYCHALCONE ON DIGESTIVE ENZYMES RELATED TO OBESITY النشاط المضاد للأكسدة والتأثير المثبط لـ 2 4 4 - هيدروكسي تشالكون على إنزيمات الجهاز الهضمي المرتبطة بالسمنة |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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The aim of this study was to investigate the antioxidant activity and inhibitory effect of 2,4,4'-trihydroxychalcone on digestive enzymes related to obesity, including sucrase, α-amylase, and lipase. The in vitro antioxidant activities of three concentrations of 2,4,4'-trihydroxychalcone (100, 300, and 500 µg/ml) were determined using 2,2-diphenyl-1-picrylhydrazyl radical scavenging, reducing power, and ferrous ion chelating assays. Moreover, in vitro inhibition of lipase, α-amylase, and sucrase enzyme activities by 2,4,4'-trihydroxychalcone was determined using a specific assay for each enzyme. 2,4,4'-Trihydroxychalcone has been shown to have antioxidant properties. 2,4,4'-Trihydroxychalcone inhibits sucrase activity. Similar to acarbose, 2,4,4'-trihydroxychalcone inhibits α-amylase activity. Inhibition of lipase by 2,4,4'-trihydroxychalcone is comparable to that of orlistat. These findings suggest that 2,4,4′-trihydroxychalcone demonstrated an antioxidant activity and can effectively inhibit the key enzymes related to obesity. |
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Supervisor |
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Dr. Hadeil Alsufiani |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1445 AH
2023 AD |
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Co-Supervisor |
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Dr. Rasha Mansouri |
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Added Date |
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Wednesday, November 1, 2023 |
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Researchers
| غينات عبدالله الظاهري | Aldhaheri, Ghaynat Abdullah | Researcher | Master | |
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