Document Details

Document Type : Thesis 
Document Title :
Synthesis and Spectra Study, Molecular Modeling, for Biological Activity of Some Drug – Based Metal Complexes
تحضير ودراسة الاطياف ونمذجة جزيئية للتاثير البيولوجي لبعض معقدات الفلزات القائمة على مركبات دوائية
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : New drugs–based metal (II) complexes were prepared by the reaction of first raw transition metals Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) in the form of MCl2.nH2O with Pitavastatin Calcium (PSC) and Rosuvastatin Calcium (RSC). The metal complexes were characterized using various spectroscopic techniques, including elemental analysis, molar conductance, magnetic moment, FT-IR, EPR spectroscopic techniques, thermographic analysis TGA, and kinetic study of metal complexes. The IR spectra suggested that the ligands were coordinated in a bidentate binding mode through the oxygen atoms of the carboxylate group in both ligands. Molar conductivities indicated that all the complexes were non-electrolytic in nature. The magnetic moment and EPR of the complexes suggested their octahedral geometries. Thermal studies were conducted to confirm the structures and analyze the thermal stabilities of the complexes. The thermodynamic parameters were determined using the Coats–Redfern and Horowitz–Metzger methods. The DNA binding study was investigated by spectrophotometric experiments and viscosity measurements, and the complexes were found to be groove binders to the DNA. The cytotoxic activity of the synthesized complexes exhibited good inhibition toward both breast carcinoma (MCF-7) and human lung cancer (A549) cell lines. The results of molecular docking displayed good correlations with experimental cytotoxicity findings. Therefore, these findings suggest that our synthesized complexes can be introduced as effective anticancer agents. Key words: Metal-based complex, Statin drugs, DNA binding, Anticancer properties, Molecular docking. 
Supervisor : Dr. Mostafa Aly Hussien 
Thesis Type : Master Thesis 
Publishing Year : 1445 AH
2023 AD 
Co-Supervisor : Dr. Dalal Ahmad Al-Ezi 
Added Date : Saturday, November 4, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
حليمه ذاكر الزبيديAlzubaidi, Halimah ThakirResearcherMaster 

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